伦敦大学Gareth教授应邀来访并做学术报告
应北京化工大学化工资源有效利用国家重点实验室卫敏教授课题组邀请, 伦敦大学Gareth教授于2019年6月24日到访实验室,并做了题为“Hyphenated differential scanning calorimetry X-ray diffraction: A powerful new technique for materials science”的学术报告。
在报告中,Gareth教授首先通过举例:活性药物成分(API)的溶解度及其在体内的作用是其物理形式的函数。因此,多形态控制在药物开发中具有根本性的重要性,以确保不同批次药物的安全性、有效性和一致性。向大家强调了对材料固态化学性质透彻了解的重要性。随后,Gareth教授指出研究多态转变的标准方法是差示扫描量热法(DSC)。但是由于该方法不能提供结构信息,则需要x射线衍射(XRD)同时进行表征。但是标准的实验室仪器需要相当长的时间来记录衍射图样(约30分钟),因此很难研究瞬态相。同时XRD和DSC仪器样品大小的差异也会影响实验数据。在抛出这个问题之后,Gareth教授随即向我们展示了解决这个问题的方法:对标准实验室DSC仪器进行改进。通过将其安装在同步x射线源上,该仪器仅需2秒就可以获得衍射图样。这样的改进使得我们能够同时进行DSC - XRD,并在标准DSC升温过程中收集大量适合精修的XRD数据。在整个报告中,Gareth教授**澎湃,语言抑扬顿挫,诙谐不乏味,并对于难以理解的部分淳淳善诱,在最后的提问环节中,Gareth教授更是亲切的走到台下和同学们面对面的讨论和交流,让我们备感温暖。通过此次报告,同学们不仅学习到了有指导作用的专业知识,而且对于科研思路的开拓有很好的借鉴和学习意义。
Gareth教授简介:
Dr. Gareth received a MChem (Hons) degree from the University of Oxford in 2002. He remained in Oxford for a DPhil (PhD) in materials chemistry working with Prof Dermot O’Hare, which was completed in 2005. Gareth then spent three years working in science programme management for the UK government, before returning to Oxford to take up a post-doctoral position in 2009. In September 2010 he joined London Metropolitan University as a Senior Lecturer in Pharmaceutical Science, and in November 2012 was appointed to the UCL School of Pharmacy as a Lecturer in Pharmaceutics. He was promoted to Associate Professor in 2016 and recognized as a Fellow of the Royal Society of Chemistry in 2017. Gareth leads a group of around 20 researchers working on a range of topics in drug delivery and vaccine formulation, with a particular interest in the development of new analytics techniques.